Studies of the interractions of cyclamate with phenprocomon
Kinawi, A.; Baumgartl, I.
Journal of Clinical Chemistry and Clinical Biochemistry 15(6): 345-348
1977
ISSN/ISBN: 0340-076X PMID: 894206 Document Number: 124036
The effect of cyclamate on the anticoagulant activity of phenprocoumon was investigated in rats after single oral doses of phenprocoumon, cyclamate, or phenprocoumon/cyclamate. By means of high pressure liquid chromatrography [HPLC] the change of the concentration of phenprocoumon per unit time in sera was determined. The anticoagulant acitivity of phenprocoumon was determined by the extension of the prothromin-time (Quick-test). It was found that cyclamate gives rise to an elevated of phenprocoumon in the blood, and a reduction of the anticoagulanting potency.