Effects of pyrazole treatment of physical status and brain biogenic amines in rats
Macdonald, E.
Medical Biology 55(2): 101-108
1977
ISSN/ISBN: 0302-2137 PMID: 865152 Document Number: 123713
Recovery of brain noradrenaline (norepinephrine, NA) from a single dose of 100 mg/kg pyrazole was rapid but after 500 mg/kg brain NA levels were still maximally reduced 3 days later and did not return to normal until 7 days after injection. Water consumption followed a similar time course at this dose. Sub-acute experiments were carried out in 2 sets of animals: those with free access to food and H2O throughout the experiment and those which during the latter half of the experiment received a known, restricted quantity of food and fluid by gastric intubation. Diet restriction did not alter the pyrazole induced decrease in brain NA and potentiated the decrease observed in the heart. A significant increase in brain 5-hydroxyindoleacetic acid was observed with pyrazole 100 mg/kg in both diet schedules. Pyrazole caused disturbances in food and H2O consumption and a decrease in locomotor activity which was only partly due to the starvation. Rectal temperature did not change. At the higher pyrazole dose in the rats fed by intubation there was incomplete emptying of the stomach. These many changes demonstrate pyrazole's nonspecificity and caution is advocated in its use combined with ethanol in research on experimental alcoholism.