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Effect of the enterotropic carcinogen 1,2-dimethylhydrazine on the level of biogenic amines in the hypothalamus of rats

Anisimov, V.N.; Pozdeev, V.K.; Dmitrievskaia, A.I.; Gracheva, G.M.; Il'in, A.P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 82(11): 1359-1361

1976

ISSN/ISBN: 0365-9615
PMID: 1016720
Document Number: 107817
The hypothalamic levels of noradrenaline (NA), dophamine (DA), serotonine (5-HT), 5-hydroxyindolacetic acid (5-HIAA) were found to be decreased in male rats 24 hours after subcutaneous injection of 1,2-dimethylhydrazine (SDMH) in a dose of 21 mg/kg. During 3 to 12 hrs after the SDMH treatment the hypothalamic level of NA was decreased, whereas the 5-HT turnover became greater. The hypothalamic histamine level increased 30 min after the SDMH injection only. In the brain stem and the great hemispheres the biogenic amine level displayed no significant changes under the effect of SDMH. The endocrine-metabolic changes due to the selected SDMH effect on the hypothalamic biogenic amine level are supposed to be of great significance in the realization of the carcinogenic action of SDMH in rats.

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