The effect of exercise on the content of biogenic amines and acetylcholine of the blood in bronchial asthma patients
Mamedov, D.T.; Goncharova, V.A.; Dotsenko, E.K.; Sinitsina, T.M.
Terapevticheskii Arkhiv 61(3): 23-27
1989
ISSN/ISBN: 0040-3660 PMID: 2741110 Document Number: 337789
The content of acetylcholine, histamine and the total amount of catecholamines were measured in blood of 33 patients with bronchial asthma, in 6 patients with preasthma and in 10 practically normal subjects before and after the use of graded exercise (bicycle ergometry). Subgroups of the patients with asthma of effort were singled out. In such patients, exercises resulted in a significant rise of histamine (p less than 0.05) or acetylcholine level (p less than 0.05). Histaminemia was mostly accompanied by an immediate obstructive response of the bronchi to exercise in the distal parts. In patients with a high acetylcholine content, obstruction of the large bronchi was mainly observed, with a slightly delayed response to exercise.