First results with a new prostaglandin E2-derivate
Schmidt-Gollwitzer, M.; Schmidt-Gollwitzer, K.; Schüssler, B.; Koch, R.; Nevinny-Stickel, J.
Geburtshilfe und Frauenheilkunde 37(12): 1030-1038
1977
ISSN/ISBN: 0016-5751 PMID: 604150 Document Number: 123616
Use of 16-phenoxy-prostaglandin E2 methane sulfonamide (SH B 286), a prostaglandin E2 derivative, as an abortifacient in 114 patients is reported. Vital signs, intrauterine pressure, and blood levels of steroid hormones, chorionic gonadotropin, and placental lactogen were noted before, during, and after administration. Extraamniotic injection of 100-250 mcg induced abortion in 80% of the 76 women observed. No severe systemic effects occurred, and vomiting (15%), nausea (25%), and uterine cramps (40%) rarely required treatment. Of 38 women receiving an intravenous drip, complete abortion was induced in 33; side effects were dose-dependent and no severe complications were seen. The lowest dose (0.5-1.5 mcg/ml, 1000 mcg total dose) was as effective as larger doses. Uterine contractions were increased by the medication, while serum hormone levels, especially progesterone, decreased. SH B 286 is shown by this study to be an effective and safe abortifacient. (Author's)