On the absorption of decongestive nose-drops-investigation with a radioactive labelled imidazoline-derivate
Münzel, M.; Eichner, H.
Laryngologie Rhinologie Otologie 54(11): 875-888
1975
ISSN/ISBN: 0340-1588 PMID: 53769 Document Number: 89742
In animal experiments, the absorption of a nasal decongestive substance after application to the nasal mucosa was studied. After an exposition-time of 60 minutes, about 1% of the substance applied could be measured in the total blood volume. An incorporation of the substance into proteins of the nasal mucosa could not be found. By means of frozen-section-autoradiography, the way of the applied decongestive substance through the mucosa could be investigated. The reasons for the relative small absorption rate are discussed. The chemical structure and the vasoconstrictory effect probably are reliable for that.