S-adenosylmethionine as a regulator of protein synthesis. Influence on plasmatic fibrinogen
Frezza, M.; Pozzato, G.; Valente, G.; Gilotta, S.; Milani, S.; Nicolini, R.
Minerva Medica 68(17): 1105-1114
1977
ISSN/ISBN: 0026-4806 PMID: 857203 Document Number: 123055
S-adenosyl-L-methionine (SAMe) is a physiological compound which plays an important role in numerous biological processes, such as transmethylations, transulphurations and aminopropylations. Starting from a study about the usefulness of the SAMe to normalize protein synthesis in old age, the drug was found to have an interesting action with respect to fibrinogen. Later research regarding a large number of patients, led us to discover after treatment for 40 days with 60 mg/die of SAMe, highly significant variations in fibrinogen values with constant normalization of this parameter, in both hypo- and hyper-fibrinogenemia. So far we don't know anything about the action of the drug on various metabolic stages of the fibrinogen; interestingly however our data exclude a rise in fibrinolysis.