Top Abstract Purchase Related
Home
>
Node
>
Subnode

Stimulation of S-adenosylmethionine synthetase in human lymphocytes by streptococcal M protein

Kotb, M.; Dale, J.B.; Beachey, E.H.

Journal of Immunology 139(1): 202-206

1987

ISSN/ISBN: 0022-1767
PMID: 3295052
Document Number: 290147
The effects of the specific antigen M5 protein of group A streptococci on AdoMet synthetase activity and AdoMet levels in peripheral blood (PB) lymphocytes were studied and were compared with the effects of the nonspecific polyclonal T cell mitogen PHA. M5 protein stimulated AdoMet synthetase activity, whereas PHA had a biphasic effect with an early inhibitory effect and a later stimulatory effect on AdoMet synthetase activity. S-Carbamyl-L-cysteine (SCC), an inhibitor of human lymphocyte AdoMet synthetase, reduced AdoMet levels and inhibited the blastogenic response of PB lymphocytes to both M5 protein and PHA. Inhibition of the response to M5 protein was stronger than that to PHA. However, the inhibitory effects of SCC were totally reversible by washing the cells. It is our hypothesis that such differences in the biochemical events triggered by specific antigen as opposed to a polyclonal mitogen may determine the direction of the functional differentiation of T lymphocytes.

Document emailed within 1 workday
Secure & encrypted payments

Quinn, A.; Adderson, E.E.; Shackelford, P.G.; Carroll, W.L.; Cunningham, M.W. 1995: Autoantibody germ-line gene segment encodes VH and VL regions of a human anti-streptococcal monoclonal antibody recognizing streptococcal M protein and human cardiac myosin epitopes Journal of Immunology 154(8): 4203-4212
Liau, M.C.; Chang, C.F.; Belanger, L.; Grenier, A. 1979: Correlation of isozyme patterns of S-adenosylmethionine synthetase with fetal stages and pathological states of the liver Cancer Research 39(1): 162-169
Sakane, T.; Green, I. 1978: Protein a from Staphylococcus aureus-a mitogen for human T lymphocytes and B lymphocytes but not L lymphocytes Journal of Immunology 120(1): 302-311
Kraus, W.; Dale, J.B.; Beachey, E.H. 1990: Identification of an epitope of type 1 streptococcal M protein that is shared with a 43-kDa protein of human myocardium and renal glomeruli Journal of Immunology 145(12): 4089-4093
Cunningham, M.W.; McCormack, J.M.; Fenderson, P.G.; Ho, M.K.; Beachey, E.H.; Dale, J.B. 1989: Human and murine antibodies cross-reactive with streptococcal M protein and myosin recognize the sequence GLN-LYS-SER-LYS-GLN in M protein Journal of Immunology 143(8): 2677-2683
Abe, J.; Forrester, J.; Nakahara, T.; Lafferty, J.A.; Kotzin, B.L.; Leung, D.Y. 1991: Selective stimulation of human T cells with streptococcal erythrogenic toxins A and B Journal of Immunology 146(11): 3747-3750
Payan, D.G.; Brewster, D.R.; Goetzl, E.J. 1983: Specific stimulation of human T lymphocytes by substance P Journal of Immunology 131(4): 1613-1615
Frezza, M.; Pozzato, G.; Valente, G.; Gilotta, S.; Milani, S.; Nicolini, R. 1977: S-adenosylmethionine as a regulator of protein synthesis. Influence on plasmatic fibrinogen Minerva Medica 68(17): 1105-1114
Bartholmös, G.; Göring, H.D.; Schwalm, I. 1983: Light scattering measurement for the determination of PHA stimulation of human lymphocytes Dermatologische Monatschrift 169(6): 394-399
Hamajima, K.; Osono, M.; Kawamura, A. 1978: Augmented mitotic response of human peripheral lymphocytes in the presence of lymphocytes from nude mice: detection of a small number of functional human lymphocytes in the explanted host Japanese Journal of Experimental Medicine 48(3): 243-250
Zhang, W.; Holzknecht, R.A.; Butkowski, R.J.; Tuchman, M. 1990: Immunochemical analysis of carbamyl phosphate synthetase i and ornithine transcarbamylase deficient livers: elevated N-acetylglutamate level in a liver lacking carbamyl phosphate synthetase protein Clinical and Investigative Medicine. Medecine Clinique et Experimentale 13(4): 183-188
Closs, O.; Saltvedt, E.; Olsnes, S. 1975: Stimulation of human lymphocytes by galactose-specific abrus and ricinus lectins Journal of Immunology 115(4): 1045-1048
Bertoglio, J.H. 1983: Monocyte-independent stimulation of human B lymphocytes by phorbol myristate acetate Journal of Immunology 131(5): 2279-2281
Mattern, T.; Flad, H.D.; Ulmer, A.J. 1998: Stimulation of human T lymphocytes by lipopolysaccaride (LPS) in the presence of autologous and heterologous monocytes Progress in Clinical and Biological Research 397: 243-254
Basevich, V.V.; Mevkh, A.T.; Varfolomeev, S.D. 1984: Kinetic mechanisms of enzyme activity of the thromboxane synthetase system. Thromboxane synthetase of human platelets Biokhimiia 49(9): 1538-1545
De Gast, G.C.; The, T.H.; Ponds, E.; Kallenberg, C. 1977: Suppression of DNA synthesis by Con A-activated human lymphocytes: Stimulation by con A bound to non-T cells unless removed after activation Clinical and Experimental Immunology 30(3): 457-464
Uzgiris, E.E.; Lockwood, S.H.; Kaplan, J.H. 1982: Oscillation of cell surface charge of human peripheral blood lymphocytes after stimulation with concanavalin a Journal of Immunology 128(5): 1975-1978
Wagner, H.; Kreher, B.; Jurcic, K. 1988: In vitro stimulation of human granulocytes and lymphocytes by pico- and femtogram quantities of cytostatic agents Arzneimittel-Forschung 38(2): 273-275
Soell, M.; Lett, E.; Holveck, F.; Schöller, M.; Wachsmann, D.; Klein, J.P. 1995: Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen, and mannan binding protein inhibits TNF-alpha release Journal of Immunology 154(2): 851-860
Jarvis, L.J.; LeBien, T.W. 1995: Stimulation of human bone marrow stromal cell tyrosine kinases and IL-6 production by contact with B lymphocytes Journal of Immunology 155(5): 2359-2368