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Human platelet fibrinogen: a protein different from plasma fibrinogen

Soria, J.; Soria, C.; Samama, M.; Poirot, E.; Kling, C.

Pathologie-Biologie 24 Suppl: 15-17

1976

ISSN/ISBN: 0369-8114
PMID: 796805
Document Number: 109464
Fibrinogen has been purified from normal and dysfibrinogenemia Metz plasmas, and from normal and from the patient's platelets. There are differences in the pattern of disc polyacrylamide gel electrophoresis between normal plasma and normal platelet fibrinogens, but the migration of the A alpha chain is similar. The abnormality of the electrophoretic mobility of the A alpha chain of plasma fibrinogen from Metz dysfibrinogenemia is not found in platelet fibrinogen of this patient. This result clearly establishes that platelet fibrinogen is a different protein from plasma fibrinogen.

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