Skeletal and soft tissue sarcomas. Treatment with adjuvant immunotherapy
Townsend, C.M.; Eilber, F.R.; Morton, D.L.
JAMA 236(19): 2187-2189
1976
ISSN/ISBN: 0098-7484 PMID: 989809 Document Number: 109463
Because there is evidence for an active immunologic response against sarcoma, a clinical trial of adjuvant immunotherapy using bacillus Calmette-Guérin (BCG) and tumor cell vaccine was begun. Eleven of 18 patients with localized soft tissue sarcoma who received immunotherapy are free of disease, compared to only 5 of 15 treated by operation alone who are free of disease. Furthermore, immunotherapy also prolonged the median disease-free interval from 7.3 months to 15 months in the patients who experienced recurrence of their disease.