Sympathomimetic effects of a newly synthesised compound (SBS-I)
Bajaj, U.K.; Sharma, V.N.
Indian Journal of Medical Research 65(3): 441-446
1977
ISSN/ISBN: 0019-5340 PMID: 924557 Document Number: 123046
A new synthetic compound (SBS-I) exhibited sympathomimetic effects, i.e., pressor response, contraction of spleen and nictitating membrane, and relaxation of intact intestine of dog and isolated rat uterus. The pressor and splenic contraction responses were blocked by tolazoline, an .alpha.-adrenergic blocking agent. The general behavioral patterns or rats and mice after drug administration, resembled that of sympathetic overactivity, e.g., salivation, piloerection, hyperthermia, urination and hyperexcitability. The compound potentiated pentobarbitone induced sleeping time in mice at higher dose, e.g., 40 mg/kg (i.p.). However, it delayed the onset of hypnosis by 10-12 min in all the doses studied. Experimentally produced tremors in dogs were immediately blocked for a period of 10-12 min with 2 mg/kg (i.v.) of the test compound. The compound had spasmogenic action on isolated rabbit ileum which was not cholinergic in nature.