Inotropic effects of the antiarrhythmic compound Bonnecor (AWD 19-166, GS 015)
Nilius, B.; Schumann, M.
Die Pharmazie 40(12): 854
1985
ISSN/ISBN: 0031-7144 PMID: 3841601 Document Number: 261148
The inotropic effects of the new antiarrhythmic compound AWD 19-166 have been studied at constantly driven isolated left atria of guinea pig (weight between 250 and 350 g). AWD 19-166 exerted dose-dependently negative inotropic effects. Half maximum effects were measured at 1.7 mg/l (n = 7). At concentrations higher than 5 mg/l the negative inotropic effects were found to be irreversible.