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The lumi-aggregometer: a new instrument for simultaneous measurement of secretion and aggregation by platelets

Feinman, R.D.; Lubowsky, J.; Charo, I.; Zabinski, M.P.

Journal of Laboratory and Clinical Medicine 90(1): 125-129

1977

ISSN/ISBN: 0022-2143
PMID: 874364
Document Number: 121925
We have developed a new instrument that simultaneously monitors aggregation and secretion of ATP from the same sample of platelets. Aggregation is determined by the usual turbidimetric method; secretion of ATP is followed by measuring luminescence from the firefly luciferase system at right angles to the aggregometer light path. Data are recorded on a two-pen strip chart recorder and reveal the temporal relations between the two platelet responses.

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