Isolation and structure determination of the metabolites of 2- (1,3-dimethyl-xanthinyl- (7) -methyl) -4-methyl-morpholine--a xantinol derivative--from rat urine
Tauscher, M.; Eckhardt, G.; Geisel, B.; Schroeder, G.
Arzneimittel-Forschung 27(12): 2344-2347
1977
ISSN/ISBN: 0004-4172 PMID: 580049 Document Number: 121503
In the urine of rats the following metabolites of the xantinol derivative 2-(1,3-dimethyl-xanthinyl-(7)-methyl)-4-methyl-morpholine were found: 2-[1,3-dimethyl-xanthinyl-(7)-methyl]-morpholine and 2-[1,3-dimethyl-xanthinyl-(7)-methyl]-4-methyl-morpholin-5-one. These compounds represent about 13.7% of the p.o. applied 2-[1,3-dimethyl-xanthinyl-(7)-methyl]-4-methyl-morpholine. Their structure has been elucidated by IR-, PMR- and mass spectrometry.
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