Effect of levamisole on malignant experimental neurinoma grown subcutaneously in a young rat: brief communication
Aleksic, S.; Drnovski, F.; Bloom, A.; Rappaport, H.; Ransohoff, J.
Journal of the National Cancer Institute 59(5): 1565-1567
1977
ISSN/ISBN: 0027-8874 PMID: 909112 Document Number: 121465
Levamisole, a drug that stimulates the immunologic defenses of the host, was tested on an experimental malignant neurinoma grown subcutaneously in young female inbred CDF rats in a 3-mo. trial. The drug resulted in prevention of tumor growth in 80% of the treated animals, whereas tumors grew in 100% of the controls. After discontinuation of the drug, none of the animals in the treated group showed evidence of tumor growth on clinical and pathologic examination 1 mo. after drug treatment was terminated. Treated animals failed to show any side effects related to levamisole on clinical and pathologic examination.