Effect of levamisole on cell sensitivity in rats with experimental Heymann's nephritis
Tareyeva, I.E.; Savitsky, S.N.; Gordovskaya, N.B.; Varshavsky, V.A.
Acta Medica Hungarica 41(2-3): 137-141
1984
ISSN/ISBN: 0236-5286 PMID: 6379593 Document Number: 225665
The development of cell-sensitization to renal antigen in rats with experimental Heymann's glomerulonephritis [GN] and the effect of levamisole on cell sensitivity were studied. Morphologic changes in GN rats appeared after 14 days and were most pronounced on days 21-28, with focal proliferation of glomerular cells, an increase of mesangium, a focal increase of the basal membrane material. After day 49 the changes improved slightly and were still the same on day 147 when a location of IgG to the glomerular basal membrane was detected. In every GN rat, cell-sensitivity to renal antigen was revealed from day 21 of the experiment till its end. Levamisole treatment decreased renal morphologic changes and abolished cell-sensitivity to renal antigen. The possible mechanisms of preventing the development of cell-sensitization in rats treated with levamisole are discussed.