A retrospective study of probable glucocorticoid-induced hepatopathy in dogs
Rogers, W.A.; Ruebner, B.H.
Journal of the American Veterinary Medical Association 170(6): 603-606
1977
ISSN/ISBN: 0003-1488 PMID: 849910 Document Number: 121005
Liver disease associated with glucocorticoid therapy or with naturally occurring adrenal cortex overactivity was detected retrospectively in hepatic biopsy specimens from 22 of 60 dogs. There was centrilobular vacuolization, perivacuolar glycogen accumulation within hepatocytes, and focal centrilobular necrosis. The predominant clinical findings were hepatomegaly, increased serum enzyme activity associated with hepatic disease, and increased bromsulphalein retention. The disease appeared to be reversible.