Glucocorticoid-induced osteoporosis
Den Uyl, D.; Bultink, I.E.M.; Lems, W.F.
Clinical and Experimental Rheumatology 29(5 Suppl 68: S93-S98
2011
ISSN/ISBN: 0392-856X PMID: 22018192 Document Number: 655572
Glucocorticoid-induced osteoporosis is one of the most important side-effects of glucocorticoid use, leading to an increased fracture risk. In this review, recent advances in the understanding of the mechanisms of glucocorticoid-induced osteoporosis are summarised. Methods to identify persons at risk for fractures are discussed, as well as the new ACR recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis (2010). Different treatment options are summarised considering the pathogenesis of glucocorticoid-induced osteoporosis. Improved insights into pathogenesis might result in development of new treatment possibilities.