Drug-induced manifestation of hereditary hepatopathy
Horváth, T.; Gógl, A.; Ruzsa, C.; Ludány, A.; Jávor, T.
Acta Medica Academiae Scientiarum Hungaricae 31(3-4): 219-228
1974
ISSN/ISBN: 0001-5989 PMID: 4469715 Document Number: 517437
Drug treatment appears to have induced the manifestation of undetected enzymopathy in 4 case studies. 2 patients had acute intermittent porphyria and 2 had Gilbert's syndrome. In acute intermittent porphyria, the effects of enzyme inducers may overproduce DALA-synthetase which may lead to an acute porphyria attack. In Gilbert's syndrome, enzyme activity is hormone-dependent and studies have shown that synthetic estrogens are inhibitory to conjugation with glucuronide. Therefore, drug use may result in the manifestation of hereditary or genetic defects.