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Proarrhythmic effects of propafenone in a woman with hepatopathy: is it always a simple drug in clinical practice?

Hrovatin, E.; Piazza, R.; Brieda, M.; Dametto, E.; Zardo, F.; Burelli, C.; Cassin, M.; Nicolosi, G.L.

Italian Heart Journal. Suppl Official Journal of the Italian Federation of Cardiology 3(7): 770-775

2002

ISSN/ISBN: 1129-4728
PMID: 12187639
Document Number: 548252
A 65-year-old woman with a history of alcoholic liver disease and presenting with fever and vomiting was admitted to an internal medicine unit. In view of recent atrial fibrillation with inadequate heart rate control, digoxin and propafenone were included in the therapeutic regimen. After a few days sinus rhythm was restored but suddenly ventricular arrhythmias with the characteristics of a non-responsive electrical storm arose shortly following the appearance of clinical symptoms of drug intoxication.

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