Anti-inflammatory activity of EU-2972, 2- (3,4-dichlorphenylamino) quinolizinium bromide
Goldenberg, M.M.; Ilse, A.C.
Archives Internationales de Pharmacodynamie et de Therapie 228(1): 153-161
1977
ISSN/ISBN: 0003-9780 PMID: 921398 Document Number: 118610
Eu-2972, a new and unique drug affecting the gastrointestinal tract, caused a dose-related inhibition of carrageenin-induced hindpaw edema in the rat. The acute anti-inflammatory effect of EU-2972 was absent in bilaterally adrenal-demedullated and in adrenalectomized rats. In the adjuvant-induced (Mycobacterium butyricum) polyarthritis rat study, daily peroral doses of EU-2972 for 14 days partially reduced primary and secondary lesions in the rat hindfeet without improving the arthritis score or body weight loss. Phenylbutazone ameliorated all signs associated with polyarthritis in rats. The acute anti-inflammatory effectiveness of EU-2972 apparently was due to a release of adrenal catecholamines and not to a direct effect or to a release of adrenal corticosteroids. A drug which releases adrenal catecholamines alone can be partially effective in reducing hindpaw lesion formation in rats with adjuvant arthritis. A drug which affects the gastrointestinal tract apparently can be effective in an acute inflammatory condition.