Lack of cross-desensitization between structurally dissimilar alpha-adrenoceptor agonists
Ruffolo, R.R.; Turowski, B.S.; Patil, P.N.
Journal of Pharmacy and Pharmacology 29(6): 378-380
1977
ISSN/ISBN: 0022-3573 PMID: 18582 Document Number: 118591
Experiments on receptor desensitization using rat vasa deferentia suggest the existence of different sites of interaction on the .alpha.-adrenoceptor for agonists of the imidazoline and phenethylamine classes.
Document emailed within 1 workday
Related Documents
Vassilev, P.P. 1995: Beta-Adrenoceptor agonists-induced desensitization in rat trachea Acta Physiologica et Pharmacologica Bulgarica 21(3): 57-62Wachsman, D.E.; Kavaler, J.P.; Sugár, I.P.; Schachter, E.N.; Gonsiorek, W.; Maayani, S. 1997: Kinetic studies of desensitization and resensitization of the relaxation response to beta-2 adrenoceptor agonists in isolated guinea pig trachea Journal of Pharmacology and Experimental Therapeutics 280(1): 332-345
Kaplan, N.M. 1985: Alpha 2-adrenoceptor agonists in the treatment of hypertension Journal of Cardiovascular Pharmacology 7(Suppl 8): S64-S66
Schmidt-Oechtering, G.U.; Becker, K. 1992: Old and new alpha 2-adrenoceptor agonists. 1. Xylazine and medetomidine Tierarztliche Praxis 20(5): 447-458
Angel, I.; Bidet, S.; Langer, S.Z. 1988: Pharmacological characterization of the hyperglycemia induced by alpha-2 adrenoceptor agonists Journal of Pharmacology and Experimental Therapeutics 246(3): 1098-1103
Svensson, T.H. 1987: Stress, central neurotransmitters, and the mechanism of action of alpha 2-adrenoceptor agonists Journal of Cardiovascular Pharmacology 10(Suppl 12): S88-S92
Blandford, D.E.; Smyth, D.D. 1990: Role of vasopressin in response to intrarenal infusions of alpha-2 adrenoceptor agonists Journal of Pharmacology and Experimental Therapeutics 255(1): 264-270
Dollery, C.T. 1976: Centrally acting alpha-adrenoceptor agonists in hypertension: mechanisms and their role in therapy Australian and New Zealand Journal of Medicine 6(3): 88-94
Donello, J.E.; Padillo, E.U.; Webster, M.L.; Wheeler, L.A.; Gil, D.W. 2001: Alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia Journal of Pharmacology and Experimental Therapeutics 296(1): 216-223
Tabrizchi, R.; Triggle, C.R. 1992: The interrelationship between the effects of captopril and nifedipine on pressor responses elicited by selective alpha-adrenoceptor agonists in the pithed rat preparation Journal of Cardiovascular Pharmacology 19(4): 562-567
Wiśniewska, R.J. 1998: Interaction of cholecystokinin (CCK-33) and its C-terminal fragments: CCK-8 and CCK-4 with alpha- and beta-adrenoceptor agonists and antagonists in the cardiovascular system of rats. Part A Polish Journal of Pharmacology 50(3): 203-212
Kazanietz, M.G.; Enero, M.A. 1990: Desensitization of the beta-2 adrenoceptor-mediated vasodilation in rat aorta after prolonged treatment with the beta-2 adrenoceptor agonist clenbuterol Journal of Pharmacology and Experimental Therapeutics 252(2): 758-764
Martin, D.J.; Lluel, P.; Guillot, E.; Coste, A.; Jammes, D.; Angel, I. 1997: Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists Journal of Pharmacology and Experimental Therapeutics 282(1): 228-235
Shi, C.Z.; Li, X.M.; Liu, Y.; Zhang, J.T. 1990: Application of mouse tail artery for the study of alpha adrenoceptor agonists and antagonists and calcium antagonists Yao Xue Xue Bao 25(3): 223-226
Maroto, R.; Calvo, S.; Sancho, C.; Esquerro, E. 1992: Alpha- and beta-adrenoceptor cross-talk in the regulation of glycogenolysis in dog and guinea-pig liver Archives Internationales de Pharmacodynamie et de Therapie 317: 35-46
Weetman, D.F.; Jahn, U.; Ismail, S.; Chadwick, M.A.; Coates, J.; Lawson, K.; Turner, N.; Thiele, K. 1983: Sgd 101/75: a sympathomimetic that can be used to identify a new subtype of alpha-adrenoceptor, the alpha 1s-adrenoceptor Methods and Findings in Experimental and Clinical Pharmacology 5(7): 425-434
Scott, P.A.; Chou, J.M.; Tang, H.; Frazer, A. 1994: Differential induction of 5-HT1A-mediated responses in vivo by three chemically dissimilar 5-HT1A agonists Journal of Pharmacology and Experimental Therapeutics 270(1): 198-208
Sanders, R.D.; Maze, M. 2007: Alpha2-adrenoceptor agonists Current Opinion in Investigational Drugs 8(1): 25-33
Barber, R.; Goka, T.J.; Butcher, R.W. 1989: Growth of S49 cells in low concentrations of beta-adrenergic agonists causes desensitization Molecular Pharmacology 36(3): 459-464
Miyagishi, A.; Nakahara, H.; Hara, Y. 1984: Adrenoceptor blocking effects of arotinolol, a new combined alpha- and beta-adrenoceptor blocking agent Archives Internationales de Pharmacodynamie et de Therapie 271(2): 249-262