Role of phospholipase A2 in anoxic injury to the energy-dependent functions of the mitochondria
Bragin, E.O.; Dergunov, A.D.; Neugodova, G.L.; Sorokovoĭ, V.I.; Vladimirov, I.A.
Voprosy Meditsinskoi Khimii 23(5): 673-676
1977
ISSN/ISBN: 0042-8809 PMID: 413264 Document Number: 118573
An increase in concentration of free fatty acids was observed simultaneously with a decrease in energy dependent functions of mitochondria (oxidative phosphorylation and Ca2+-accumulating ability) after their preincubation under anoxic conditions in vitro with Ca2+ ions (11-14 nmol/mg of mitochondrial protein). Impairment of mitochondria and accumulation of fatty acids were prevented by inhibitors of phospholipase A2 from mitochondria. The anoxic impairment of mitochondria appears to be caused by Ca2+-activated phospholipase A2.