Detection of platelet-bound IgG with 125I-labelled staphylococcal protein a
Kekomäki
Medical Biology 55(2): 112-114
1977
ISSN/ISBN: 0302-2137 PMID: 865154 Document Number: 117459
125I-labelled protein A from Staphylococcus aureus binds effectively with platelets coated either with specific antibodies or with unrelated immune complexes. Protein A can therefore be used to measure these serum factors. A prior dilution of the serum enhances markedly the reactivity of the serum in idopathic thrombocytopenic purpura. This may be due to abolished inhibition exerted by normal monomeric IgG.
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