A human IgA myeloma protein interacting with staphylococcal alpha-toxin and protein a
Dalen, A.; Grov, A.; Matre, R.; Myking, O.L.
Clinical and Experimental Immunology 27(3): 421-424
1977
ISSN/ISBN: 0009-9104 PMID: 862231 Document Number: 115717
High anti-staphylolysin activity was found in the serum from a patient with multiple myeloma. The activity was confined to the monoclonal IgA protein and was dependent on an intact Fc part of the molecule. An Fc-dependent interaction with protein A was also demonstrated. In addition, a part of the monoclonal IgA was found to be complexed with alpha2-macroglobulin. The results imply an unusual Fc-reactivity of the IgA protein.