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Effect of aminazin on the enzymatic oxidation of lipids

Eluashvili, I.A.; Pashinova, T.P.; Bogdanova, E.D.; Kagan, V.E.; Prilipko, L.L.

Biulleten' Eksperimental'noi Biologii i Meditsiny 84(9): 323-326

1977

ISSN/ISBN: 0365-9615
PMID: 21009
Document Number: 116169
An inhibitory effect of chlorpromazine on the enzymatic NADPH-dependent lipid peroxidation in rat liver microsomal fraction was found. This inhibition was caused by the 1) antioxidative effect of hydroxy-derivatives appearing during the oxidative metabolism of chlorpromazine with NADPH-dependent microsomal oxygenases, and by the 2) competition for reduced components of electron-carriers between the NADPH-dependent processes: chlorpromazine metabolism and lipids peroxidation.

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