Modifying effect of DDT and of its various metabolites on the toxic effect of 7,12-dimethylbenz (alpha) anthracene
Chemeris, G.I.; Turusov, V.S.
Voprosy Onkologii 23(5): 71-75
1977
ISSN/ISBN: 0507-3758 PMID: 407719 Document Number: 115608
In rats a preliminary three times injection of DDT in doses of 10 and 100 mg/Kg eliminated completely DMBA (30 mg/per 100 g of weight) lethal effect and prevented or decreased the development of adrenal necrosis. Among the metabolites under study (DDT, DDON, DDMU, DDE, DDA, DVR) DDE was found to render the strongest protective action in its single administration in a dose of 10 mg/Kg a day before the exposure to DMBA.
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