Inhibition of the blastomogenic effect of 7,12-dimethylbenz (a) anthracene in female rats by buformin, diphenin, a polypeptide pineal extract and L-DOPA
Anisimov, V.N.; Ostroumova, M.N.; Dil'man, V.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 89(6): 723-725
1980
ISSN/ISBN: 0365-9615 PMID: 6772259 Document Number: 164125
Female rats were treated with buformin, phenytoin, polypeptide pineal extract, L-DOPA or buformin combined with L-DOPA during 3 weeks before intravenous injections of DMBA (1.5 mg 6 times with one-week intervals) over a period of carcinogen injections and after it till the animals' death. The overall tumour incidence in the control group was 97%, while in buformin, phenytoin, pineal extract, L-DOPA and buformin + L-DOPA treated groups it amounted to 55, 71, 80, 50 and 62%, respectively (P < 0.05). The incidence of mammary adenocarcinoma amounted to 81, 36, 55, 26, 25 and 19%, respectively (P < 0.05). The mechanisms of the similar effects the drugs belonging to different classes produce on chemical carcinogenesis are discussed.