Prolactin release inhibiting and stimulating factors in the hypothalamus
Arimura, A.; Schally, A.V.
Advances in Experimental Medicine and Biology 87: 237-252
1977
ISSN/ISBN: 0065-2598 PMID: 19952 Document Number: 115247
Catecholamines, especially noradrenaline and dopamine, and GABA extracted from porcine hypothalamic tissue were found to possess prolactin release inhibiting factor (PIF) activity in vivo and in vitro. However, more work is needed to determine whether these effects are physiological or pharmacological. Until this and until the chemical nature and biological roles of other substances with PIF activity are clarified, no conclusion as to the nature of the physiological inhibitor of prolactin release should be made.