The effect of obesity and drastic caloric restriction on serum prolactin and thyroid stimulating hormone

Wilson, J.H.; Lamberts, S.W.

International Journal of Obesity 5(3): 275-278

1981


ISSN/ISBN: 0307-0565
PMID: 7275464
Document Number: 75
In a group of moderately obese women on weight maintenance diets, prolactin (PRL) and thyrotropin (TSH) responses to thyroliberin (TRH) were studied; the TRH tests were repeated during treatment with a 320-kcal diet, with and without the addition of triiodothyronine (T3). Basal and peak PRL values after stimulation were not significantly different in the obese patients before dietary restriction from those in nonobese controls. During use of the diet the PRL response to TRH was significantly lower than the initial value; basal PRL did not change. The percentage reduction in PRL response showed a significant positive correlation with the percentage decrease in serum T3. T3 treatment, 75 mu g daily, however, was associated with a further significant decrease in the PRL response to TRH. Plasma oestradiol did not change with use of the diet. TSH response to TRH was normal in those patients and did not change with the diet alone. T3 treatment resulted in almost complete suppression of the TSH response.

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The effect of obesity and drastic caloric restriction on serum prolactin and thyroid stimulating hormone