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PHA dose dependent defect in lymphocyte stimulation and E-rosette-forming cells in untreated Hodgkin's disease

Land, J.M.; Litwin, J.; Bigel, P.; Oberling, F.; Mayer, S.

Acta Haematologica Polonica 8(2): 131-134

1977

ISSN/ISBN: 0001-5814
PMID: 329629
Document Number: 114018
14 untreated patients with Hodgkin's disease were tested for lymphocte reactivity in vitro to optimal and suboptimal doses of PHA. A PHA dose-dependent defect in lymphocyte stimulation was demonstrated in patients when compared with a group of normal individuals. No correlation between the in vitro defect and decreased absolute number of E-rosette-forming cells (T-lymphocytes) in peripheral blood was found.

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