An analysis of the characteristics of the adrenergic neurone blocking action of dimethylphenylpiperazinium
Jayasundar, S.; Vohra, M.M.
Archives Internationales de Pharmacodynamie et de Therapie 227(1): 23-29
1977
ISSN/ISBN: 0003-9780 PMID: 901069 Document Number: 112382
An analysis of the characteristics of the adrenergic neuron blocking action of 1,1-dimethyl-4-phenylpiperazinium (DMPP) was undertaken using isolated rat vasa deferentia. DMPP (1 .times. 10-6-1.5 .times. 10-5 g/ml) reduced progressively the contractile response to transmural stimulation (TMS) in a dose-dependent manner without inhibiting the response to exogenous norepinephrine. The DMPP-induced inhibition was not reversed by washing but could be antagonized by dexamphetamine in a concentration which did not by itself affect the response to TMS. Among other sympathomimetic amines tested, methamphetamine, ephedrine, phenylpropranolamine and mephentermine were effective in antagonizing DMPP-induce inhibition. High Ca (5 mM) reversed but did not prevent the DMPP-induced inhibition. DMPP reduced preferentially responses to high frequencies of stimulation without affecting those to low.