Beta-adrenergic blocking drugs and renal function
Walters, L.; Dormehl, I.; Goosen, D.J.; Avenant, J.C.; Du Plessis, M.; Jacobs, N.; Schoeman, H.S.
South African Medical Journal 64(15): 572-573
1983
ISSN/ISBN: 0256-9574 PMID: 6137878 Document Number: 214263
A baboon model was used to investigate the effects of atenolol, nadolol, sotalol and labetalol on renal function. The glomerular filtration rate (GFR) and renal blood flow (RBF) were measured, using radionuclides and a gamma camera, before and after 1 week's oral administration of these drugs. All the drugs caused an increase in the GFR, but this reached statistical significance only in the cases of sotalol (P less than 0,025) and labetalol (0,05 less than P less than 0,10). The RBF was not significantly changed, although it decreased in all cases.