Significance of the dopamine-blocking and m-choline-blocking components in the antiapomorphine action of neuroleptics
Zharkovskiĭ, A.M.; Langel, I.L.; Chereshka, K.S.; Zharkovskaia, T.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 103(3): 317-319
1987
ISSN/ISBN: 0365-9615 PMID: 2881585 Document Number: 299632
In experiments on rats and mice the correlation between the ability of neuroleptics to antagonize apomorphine induced stereotypy and to block central dopamine and muscarinic acetylcholine receptors was studied. The analysis showed significant correlation (v = 0.76; P less than 0.05) between antistereotypic effects of drugs and their ability to inhibit 3H-spiperone binding to rat striated tissue. However, no correlation was found between antistereotypic effect of neuroleptics and their ability to block 3H-quinuclidinyl benzylate binding or arecoline-induced tremor.