Similarity of the carbohydrate structures of H-2 and Ia glycoproteins
Freed, J.H.; Nathenson, S.G.
Journal of Immunology 119(2): 477-482
1977
ISSN/ISBN: 0022-1767 PMID: 560414 Document Number: 112084
The glycopeptides produced by pronase digestion of two H-2K, two H-2D, and three Ia glycoprotein antigens were examined for size and charge. The glycopeptides derived from all of the antigens examined were found to have m.w. of 3250 +/- 200 daltons with a similar and variable composition of sialic acid residues. These data, when combined with the similarity in monosaccharide incorporation, suggest that the general parameters of the carbohydrate structure of the Ia glycoproteins from different I subregions and H-2 glycoproteins are highly similar if not identical.