Changes in rabbit skeletal muscle histone concentration at different periods following denervation
Dambinova, S.A.
Biokhimiia 41(2): 324-327
1976
ISSN/ISBN: 0320-9725 PMID: 1276272 Document Number: 107718
Dynamics of changes in histone fractions isolated from nuclei of rabbit skeletal muscles after the denervation is investigated by means of ion-exchange chromatography on CM-cellulose and polyacrylamide gel electrophoresis. It is shown that the content of arginine-rich histone fraction F2a1 is significantly increased, and that of lysine-rich histone fraction F1 is decreased on the sixth day after the denervation. Pre-operational injections of actinomycin D prevented these changes. The early suggestion about nervous control of transcription in rabbit skeletal muscles is confirmed.