Methodological contribution to the controlled measurement of platelet aggregation
Ohnhaus, E.E.; Beveridge, T.
Schweizerische Medizinische Wochenschrift 106(40): 1365-1366
1976
ISSN/ISBN: 0036-7672 PMID: 1006255 Document Number: 107120
Collagen-induced platelet aggregation was investigated in healthy volunteers under well defined experimental conditions. The Born aggregometer was used and the two parameters studied were the maximum amount and velocity of aggregation. Under these experimental conditions no significant differences in measurements on 3 consecutive days were found. In addition, identical results were obtained in the same volunteers 4 and 8 weeks following the first experimental period. This experimental procedure was therefore used to test a new nonsteroid anti-inflammatory agent, RU 43-715, for its effect on platelet aggregation. Furthermore, a controlled crossover study using 3 different substances was performed. In the light of the results in the present study, controlled studies on platelet aggregation can be performed even over on even longer period of time under the experimental conditions described.