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Influence of cerebrolysin (r) on the resistance of rats to anoxia

Trojanová, M.; Karásek, F.; Pruzková, V.; Mourek, J.

Physiologia Bohemoslovaca 25(4): 319-323

1976

ISSN/ISBN: 0369-9463
PMID: 135987
Document Number: 106813
Single injections of Cerebrolysin(R) did not affect the resistance of rats to anoxia, irrespective of age. Cerebrolysin(R) significantly raised the resistance of the young of females injected ten times i.p. with the same dose during pregnancy. The repeated (5-fold) administration of Cerebrolysin(R) significantly raised the resistance of 35-day-old rats to anoxia and, in high concentrations, it also increased the resistance of adult rats. The effect of Cerebrolysin(R) is correlated to the proportion of amino acids, aligopeptides and the nucleotides they contain. The mere administration of a mixture of amino acids or of some other hydrolysate (Testolysin) was ineffective in this respect.

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