Influence of age on the modifications of cerebral electrogenesis in the curarized rat induced by acute and repeated asphyxic anoxia
Van den Driessche, J.; Linée, P.; Le Pollès, J.B.; Lacroix, P.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 172(2): 325-329
1978
ISSN/ISBN: 0037-9026 PMID: 150922 Document Number: 131027
In curarized rats, acute and iterative asphyxic anoxia produced large modifications of the cerebral electrogenesis, whose intensity could be evaluated, during each anoxia, by measurements of three parameters : the resistance to anoxia, the post-asphyxic recuperation and the cerebral electric silence. Comparative trials, carried out on animals of the same stock, showed that the cerebral sensibility towards anoxia was very different according to their age : maximal sensibility in 2 or 28 months old rats, minimal sensibility between 8 to 15 months. These results are discussed in terms of choice of animal material and specially of the age of rats used for study of the cerebral anoxia, as well as for the study of cerebral anti- hypoxic drugs.