Familial renal disease in Norwegian Elkhound dogs: physiologic and biochemical examinations
Finco, D.R.
American Journal of Veterinary Research 37(1): 87-91
1976
ISSN/ISBN: 0002-9645 PMID: 942838 Document Number: 104664
Histological studies revealed varying degrees of renal disease in 21 of 56 progeny from a line of inbred Norwegian Elkhounds. This breed has a low glomerular filtration rate (GFR) (which may indicate impaired glomerular capillary permeability), and affected animals had a reduced ability to concentrate urine, when water was withheld for 24 hours. Haematologically affected dogs has fewer monocytes, and had hyperamylasaemia and decreased phenolsulphonphthalein excretion. Urine analyses showed that affected dogs had urine of low specific gravity, and increased urinary Ca excretion (probably an effect rather than cause of the disease), and some also had glucosuria which was unrelated to hyperglycaemia, and hyposthenuria. Other parameters (urinary pH, GFR, effective renal plasma flow, plasma and urinary alpha -amino N, distribution of various amino acids in plasma, tissue and urine, serum Ca, and blood pressure,) did not differ significantly from normal. The interval between detection of the disease and the onset of azotaemia varied from 0-56 months or more.