Coprecipitates of trifluoperazine embonate and polymers: duration action by intramuscular route
Florence, A.T.; Haq, M.E.; Loveless, A.H.
Journal of Pharmacy and Pharmacology 28(7): 601-602
1976
ISSN/ISBN: 0022-3573 PMID: 8622 Document Number: 103501
Coprecipitates of trifluoperazine embonate and 2 polymers, poly DL-aspartic acid and polymethylmethacrylate (PMMA), were tested in beagle dogs (10-17 kg). Doses of 5mg kg-1 were administered by deep i.m. injection. The readily prepared formulations described showed a prolongation of activity comparable with that obtained with nylon microcapsules in similar experiments. The polyaspartic acid preparation was less effective than one of the PMMA preparations; the relatively high solubility of the polyamino-acid in body fluids was probably a factor in the limited duration of activity in animals. In vitro dissolution experiments proved of limited use in ranking the effectiveness of these formulations as prolonged release agents.