Pharmacology and mechanism of action of opioids administered by the peridural route
Chauvin, M.
Cahiers d'Anesthesiologie 39(2): 87-90
1991
ISSN/ISBN: 0007-9685 PMID: 1678678 Document Number: 380010
The pharmacokinetics and pharmacodynamics of spinal narcotics are very important to determine dosage and intervals with bolus administration. Among known factors that may effect narcotic activity, lipid solubility seems to be the most important factor determining onset, greater dermatomal spread and longer duration of action than more lipid-soluble narcotics. This dermatomal spread is associated to a delayed respiratory depression which necessitates precautions and surveillance.