Pharmacokinetics of fentanyl administered via peridural route in the woman in labor
Lampl, E.; Garen, C.; Levron, P.; Pathier, D.; Cousin, M.T.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction 15(5): 603-607
1986
ISSN/ISBN: 0368-2315 PMID: 3760471 Document Number: 273156
Seven women in labour received a single epidural dose of 0.8 mcg/kg of fentanyl together with bupivacaine. A pharmacokinetic study was performed of the fentanyl. As previously described, plasma concentrations were low. However, wide variations and important fluctuations were observed between different individuals with frequent late second peaks. The explanation for these second peaks of plasma fentanyl is discussed. The dose of fentanyl used in epidural administration for pain relief in labour must not be over 1 mcg/kg in order to avoid toxic levels, in the fetus.