Treatment of acute pain of ureteral and biliary colic with naproxen sodium administered by the parenteral route
Marsala, F.; Cavrini, P.; Bufalino, L.; Gardini, F.
International Journal of Clinical Pharmacology Research 6(6): 495-500
1986
ISSN/ISBN: 0251-1649 PMID: 3804521 Document Number: 280817
Non-steroidal, anti-inflammatory agents (NSAIDs), well known inhibitors of prostaglandins, have been used in the treatment of biliary and ureteral pain since the end of the 1970s. The efficacy and tolerance of a new injectable formulation of naproxen sodium in ureteral and biliary pain was investigated in 77 out-patients, observed in an emergency ward, and affected by acute lithiasic symptomatology. Forty-four patients received one 275 mg vial of naproxen sodium intamuscularly, while 33 patients were given one vial at the same dosage intravenously. In 56% of the cases complete relief of pain was achieved within 30 minutes of injection, while in 86% pain was completely relieved or greatly decreased within one hour. Side-effects (nausea, vomiting) occurred in three patients, but were linked to a simultaneous aggravation of the ureteral colic.