Naproxen sodium for OB/GYN use, with special reference to pain states: a review
Edgren, R.A.; Morton, C.J.
International Journal of Fertility 31(2): 135-142
1986
ISSN/ISBN: 0020-725X PMID: 2875035 Document Number: 273301
Naproxen sodium, a nonsteroidal anti-inflammatory drug that blocks prostaglandin synthesis, has been shown to be effective for relief of mild to moderate pain. This article summarizes the literature on the efficacy of the naproxen compounds in the treatment of the following conditions: primary and secondary dysmenorrhea, IUD insertion, suction curettage, postpartum pain, pelvic inflammatory disease, gynecologic surgery, menorrhagia, premature labor, and menopause. Since naproxen does not affect the reproductive cycle, it appears to be ideal for obstetrics-gynecology use. Pediatricians, family practitioners, internists, surgeons, and geriatric specialists will also encounter patients requiring relief from pain caused by gynecologic pathology. The combined therapeutic use of nonsteroidal anti-inflammatory drugs and antibiotics for infections of the female reproductive tract appears indicated. The literature has established therapeutic success with naproxen and naproxen sodium as compared to a placebo in the treatment of dysmenorrhea and pain associated with IUD insertion, suction curettage, and postpartum conditions; joint pain in menopausal women; pain and inflammation associated with pelvic infections; and gynecologic surgery.