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The effect of prolonged vasopressin administration on the level and metabolism of catecholamines in the rat brain and kidneys

Szmigielska, H.

Acta Physiologica Polonica 27(3): 259-264

1976

ISSN/ISBN: 0044-6033
PMID: 7918
Document Number: 103271
Dopamine (DA) and noradrenaline (NA) levels and activities of the enzymes metabolizing catecholamines were determined in the rat brain and kidneys during prolonged (4 wk) administration of lysine vasopressin (LVP) and 2 wk after its withdrawal. DA level was elevated during the whole experimental period. The Na level increased mainly after LVP withdrawal. Dopa-decarboxylase activity was elevated in all the experimental animals. Tyrosine and dopamine-.beta.-hydroxylase activities increased at the final period of LVP administration and after its withdrawal. Activities of MAO were markedly increased only after 3 wk of LVP administration.

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