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The effect of prostaglandin E1 on body temperature, catecholamines and stress hormones during prolonged surgery

Okuda, M.; Amano, H.; Furuhashi, K.; Nakai, Y.

Masui. Japanese Journal of Anesthesiology 45(1): 30-37

1996

ISSN/ISBN: 0021-4892
PMID: 8865722
Document Number: 457235
The effects of prostaglandin E-1 (PGE-1) on body temperature, catecholamines and stress hormones were evaluated in 10 patients undergoing elective prolonged surgery over 12 hours. PGE-1 (0.03 mu-g cntdot kg-1 cntdot min-1) was administered in 5 patients and was not administered in 5 patients. Deep skin-surface temperature gradients were 5.1+-2.3 degree C in PGE-1 non-administered group and 0.8+-0.9 degree C in PGE-1 administered group (P lt 0.05). Pharyngeal-skin surface temperature gradients were 8.8 +- 2.1 degree C in PGE-1 non-administered group and 1.5+-1.5 degree C in PGE-1 administered group (P lt 0.05). There were no significant differences between the two groups in respects to catecholamines, stress hormones, lactate level and blood sugar. PGE-1 0.03 mu-g cntdot kg-1 cntdot min-1 is effective in maintaining peripheral circulation without causing body temperature changes during prolonged surgery.

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