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The positive effect of short-term haloperidol administration on the dysfunction of brain metabolism and neuronal activity

Kopytova, F.V.; Dovedova, E.L.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 98(6): 706-713

2012

ISSN/ISBN: 0869-8139
PMID: 23013008
Document Number: 659334
Chronic amphetamine injection increased spontaneous neuronal activity in sensomotor cortex and decreased spike activity in caudate nucleus. The neuronal ability to perform the conditioned reactions was greater in the cortex and smaller in the nucleus caudatus. By biochemical investigations it was showed the hyperactivity of dopaminergic system in the caudate nucleus compared to that in sensomotor cortex. During chronic amphetamine administration haloperidol caused effects similar to the ones caused by amphetamine on neuronal spike activity in sensomotor cortex and did not influence spike activity and neuronal conditioned reactions in the caudate nucleus. The short-term haloperidol action reduced the enzymes activity and particularly the biogenic amines level leading to the normalization of transmitter metabolism.

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