The effect of the reciprocal relationship of Ca2+ and cAMP on the control of beating in cultured rat heart cells
Harary, I.; Wallace, G.A.
Recent Advances in Studies on Cardiac Structure and Metabolism 12: 635-643
1976
ISSN/ISBN: 0363-5872 PMID: 202002 Document Number: 102853
The demonstration of Ca2+ control of the cAMP level in heart cells and the localization of the Ca2+ activator protein of cAMP phosphodiesterase on the sarcoplasmic reticulum (SR) have led us to postulate a model whereby the Ca2+ flux is related to the cAMP flux. The model suggests that the increase in cytosol Ca2+ automatically results in an increase in SR Ca2+ and a subsequent decrease in cAMP to allow for the periodic flux of Ca2+ and cAMP in the contraction cycle.