Glycogen levels and peripheral mechanisms of glucose-induced spppression of feeding
Vanderweele, D.A.; Skoog, D.R.; Novin, D.
American Journal of Physiology 231(6): 1655-1659
1976
ISSN/ISBN: 0002-9513 PMID: 990103 Document Number: 102747
Rabbits deprived of food for 0, 2, 4, 6, 8, 16 and 24 h were assessed for glucose-induced feeding suppression, refeeding after deprivation and liver glycogen. Previously, a relationship between liver glycogen and the transition from duodenal to hepatic glucose suppression was hypothesized. In duodenally cannulated rabbits, the infusion of 10 ml of isotonic glucose in awake, free-feeding animals significantly suppressed foood intake but did not do so in those food deprived for 2, 4, 6, 8, 16 or 24 h. In hepatic-cannulated rabbits, similar amounts of glucose significantly suppressed food intake in 4-, 6-, 16- and 24-h-deprived animals. Refeeding after deprivation increased as a function of continued deprivation until 6 or 8 h, when refeeding reached asymptote, or decreased through 24-h deprivations. In agreement with these observations, liver glycogen showed a sharp decline between 4, 6 and 8 h of deprivation (depending on circadian cycle). Liver glycogen depletion, or some correlate, may alter liver glucostatic regulation and may determine refeeding after deprivation.